1.
Chinese Journal of Endocrinology and Metabolism
;
(12): 152-154, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-391239
ABSTRACT
To explore the effect of high glucose on the NF-κB/IκB signal pathway in cultured rat glomerular mesangial cells. The results showed that high glucose increased the degradation of IκB-α and the translocation to nucleus of NF-κB. These changes could be reverted mostly by MG132, a proteasome inhibitor. It suggests that the activation of the NF-κB signal pathway by high glucose concentration may probably be via the ubiquitin-proteasome pathway.